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Effect of Monocular Deprivation on Uptake and Binding of [ 3 H]Glutamate in the Visual System of Rat Brain
Author(s) -
Schliebs Reinhard,
Kunert Erich,
Bigl Volker
Publication year - 1984
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1984.tb05414.x
Subject(s) - lateral geniculate nucleus , superior colliculus , monocular deprivation , glutamate receptor , geniculate , visual cortex , neuroscience , sensory deprivation , superior colliculi , chemistry , visual system , biology , nucleus , anatomy , biochemistry , ocular dominance , receptor , sensory system
[ 3 H]Glutamate uptake and binding studies were performed in the visual cortices, lateral geniculate nuclei (LGN), and superior colliculi of 3‐month‐old rats with one eyelid surgically closed from postnatal day 10 (monocular deprivation). Uptake and binding were highest in the lateral geniculate nucleus followed by the visual cortex (69% and 15%, respectively compared to LGN values) and the superior colliculus (32% and 59% of LGN values). Monocular deprivation did not affect [ 3 H]glutamate uptake in any of the visual regions examined. However, a 46% decrease in [ 3 H]glutamate binding in the lateral geniculate nucleus ipsilateral to the sutured eye was detected. Binding levels in other regions were not affected.