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Myelin Gangliosides in Developing Rats: The Influence of Maternal Ethanol Consumption
Author(s) -
Gnaedinger Jean M.,
Noronha Antonio B.,
Druse Mary J.
Publication year - 1984
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1984.tb02784.x
Subject(s) - ethanol , myelin , chemistry , consumption (sociology) , myelin sheath , biochemistry , central nervous system , biology , neuroscience , social science , sociology
The present study examined myelin gangliosides in the developing offspring of rats that were pair‐fed control or ethanol liquid diets prior to and during gestation. Between 17 and 31 days of age, we observed an increase in the proportion of G M1 in myelin (from 15% to 38% of ganglioside sialic acid) and a decrease in the proportion of G T1b (from 26% to 4%). G M4 was detected at all ages examined. Between 17 and 31 days of age, there was an increase in the proportion of N ‐acetylman‐nosamine‐derived radioactivity associated with G M1 (from 16% to 22%) and G M4 (from 5% to 13%), and a decrease in that associated with G T1b (from 24% to 4%). Small, but sygnificant (p < 0.05), developmentally related differences were found in G D2 and G D3 . Detection of G M4 in myelin of young rats in the present study appears to depend on the use of nonpartitioning methods of ganglioside extraction. Although the distribution of myelin gangliosides and radioactivity was near‐normal in ethanol‐treated pups, there was a consistent decrease in the proportion and radioactivity associated with the major myelin ganglioside, G M1 .