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Distribution of Three Enzymes of γ‐Aminobutyric Acid Metabolism in Monkey Retina
Author(s) -
Pusateri Mary Ellen,
Carter Joyce G.,
Berger Susamma J.,
Lowry Oliver H.
Publication year - 1984
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1984.tb02782.x
Subject(s) - inner plexiform layer , gaba transaminase , glutamate decarboxylase , inner nuclear layer , aminobutyric acid , retina , transaminase , outer plexiform layer , ganglion , succinate dehydrogenase , biochemistry , biology , ganglion cell layer , glutamate receptor , chemistry , biophysics , enzyme , anatomy , neuroscience , receptor
The distributions of glutamate decarboxylase (EC 4.1.1.15), γ‐aminobutyric acid transaminase (EC 2.6.1.19), and succinate semialdehyde dehydrogenase (EC 1.2.1.24) were determined in monkey retina. The decarboxylase was almost restricted to the inner plexiform layer. The transaminase was also highest in this layer, but activities were 40% as high in the adjacent third of the inner nuclear layer and in the ganglion cell and fiber layers. Succinate semialdehyde dehydrogenase was distributed very differently. Although it also showed a peak of activity in the inner plexiform layer, there was a second equal peak in the photoreceptor inner segment layer and a smaller peak in the outer plexiform layer, regions where both γ‐aminobutyric acid transaminase and glutamate decarboxylase were essentially absent.