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Effect of Cerebral Puncture on Brain Protein Synthesis in Adult and Young Rodents
Author(s) -
Dunlop David S.,
McHale Denise M.,
Lajtha Abel
Publication year - 1984
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1984.tb02770.x
Subject(s) - protein biosynthesis , medicine , biology , pharmacology , endocrinology , chemistry , biochemistry
In adult mice cerebral puncture results in an inhibition of brain protein synthesis, as suggested previously by Dunn (1975). The inhibition is apparent within a few minutes but subsides by 15 min after puncture. The percent inhibition therefore depends on the length of time between the puncture and the measurement. Mice receiving a puncture were less active than controls, and a decrease in brain temperature was observed in these animals. The decrement is, however, too small to account for the inhibition of synthesis. Diphenylhydantoin had no effect on the inhibition. Cerebral puncture of young mouse (7‐day‐oId) or rat (8‐day‐old) brain induced no inhibition of brain protein synthesis.