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Release of Aspartate and Glutamate Caused by Chloride Reduction in Synaptosomal Incubation Media
Author(s) -
Hardy J. A.,
Boakes R. J.,
Thomas D. J. E.,
Kidd A. M.,
Edwardson J. A.,
Virmani M.,
Turner J.,
Dodd P. R.
Publication year - 1984
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1984.tb02763.x
Subject(s) - incubation , glutamate receptor , chemistry , synaptosome , chloride , amino acid , neurotransmitter , biochemistry , glutamic acid , membrane , organic chemistry , receptor
Release of the amino acid neurotransmitter candidates aspartate and glutamate from synaptosomes can be stimulated by reduction of [Cl − ] in the incubation medium by replacement with the impermeant anions pro‐pionate and isethionate. Replacement by the permeant anion Br − is without effect on amino acid release. This release offers a biochemical method of studying the Cl − ion channel in CNS membrane. Key Words: Synaptosomes — Chloride — Transmitters — Release — Amino acid—Permeability. Hardy J. A. et al . Release of aspartate and glutamate caused by chloride reduction in synaptosomal incubation media.