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Effect of Ethanol on Rat Brain Polyphosphoinositides
Author(s) -
Shah I. R.,
Uma S.,
Ramakrishnan C. V.,
Hauser G.
Publication year - 1984
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1984.tb02762.x
Subject(s) - ethanol , neuroscience , chemistry , psychology , biochemistry
Female rats were allowed to consume ethanol during gestation and lactation, and brain polyphosphoinositides of the 21‐day‐old pups were quantified. Ethanol intake prevented the disappearance of the metabolically labile pools of phosphatidylinositol‐4‐phosphate and phosphatidylinositol‐4,5‐bis‐phosphate, which are rapidly degraded in the control group. In contrast, preweaning undernutrition left the size of these pools virtually unchanged, indicating a differential effect of the two nutritional regimens. Key Words: Polyphosphoinositides—Labile pools—Ethanol—Brain of offspring—Phosphati‐dylinositol ‐ 4 ‐ phosphate—Phosphatidylinositol ‐ 4,5 ‐bis‐phosphate—Ethanol feeding—Undernutrition (preweaning). Shah I. R. et al. Effect of ethanol on rat brain polyphosphoinositides.