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Amino Acids in Plasma and CSF and Monoamine Metabolites in CSF: Interrelationship in Healthy Subjects
Author(s) -
Hagenfeldt L.,
Bjerkenstedt L.,
Edman G.,
Sedvall G.,
Wiesel F.A.
Publication year - 1984
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1984.tb02756.x
Subject(s) - homovanillic acid , cerebrospinal fluid , monoamine neurotransmitter , amino acid , endocrinology , medicine , chemistry , biogenic amine , plasma concentration , neurotransmitter , serotonin , biochemistry , central nervous system , receptor
Plasma and cerebrospinal fluid (CSF) concentrations of amino acids were measured in 65 healthy volunteers (50 men and 15 women). The CSF levels of the monoamine metabolites homovanillic acid (HVA), 3‐methoxy‐4‐hydroxyphenylethylene glycol (MOPEG), and 5‐hydroxyindoleacetic acid (5‐HIAA) were also determined. Sex differences were observed in both plasma and CSF amino acid levels as well as in the relationship between these concentrations. No significant correlations were observed between the CSF levels of HVA and 5‐HIAA, and the concentrations of their precursor amino acids in either plasma or CSF. The MOPEG level in CSF correlated positively with the plasma concentrations of several amino acids.