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Positional Distribution of Acyl and Alk‐1‐enyl Groups in Grey and White Matter Ethanolamine and Choline Phosphoglycerides of a Marsupial, the Koala ( Phascolarctos cinereus )
Author(s) -
Naughton Joan M.,
Trewhella Maurice A.
Publication year - 1984
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1984.tb02737.x
Subject(s) - grey matter , ethanolamine , polyunsaturated fatty acid , white matter , biology , choline , chemistry , biochemistry , fatty acid , medicine , magnetic resonance imaging , radiology
The major phosphoglycerides in grey and white matter from the brain of the koala have been separated and examined. The major polyunsaturated fatty acids present in both the diacyl‐ and alk‐1‐enyl acylglycerophosphorylethanolamines from grey matter were 22:6ω3, 20:4ω6, and 22:4ω6. In both grey and white matter, 22:6ω3 and 20:4ω6 were concentrated in the 2‐position of diacylglycerophosphorylethanolamines and 22:4ω6 in the 2‐position of alk‐1‐enylacylglycerophos‐phorylethanolamines; polyunsaturated fatty acid levels were higher in diacylglycerophosphorylethanolamines. Ethanolamine phosphoglyceride fractions from grey matter were enriched in polyunsaturated fatty acids compared with those from white matter. The acyl groups 18:0, 18:1, and 16:0 and their alk‐1‐enyl analogues were prominent in grey and white matter ethanolamine phosphoglycerides; 18:1 was dominant in white matter alk‐1‐enylacylglycerophosphorylethanolamines. The plasmalogen composition of ethanolamine phosphoglycerides was 55% in grey matter and 76% in white matter. Choline phosphoglycerides contained negligible plasmalogen and low polyunsaturated fatty acid levels. Diacylglycerophosphorylcholine was characterized by high levels of 16:0 and 18:1. Similar acyl group distributions were estimated in the 1‐position in both grey and white matter, 16:0 being present at >50%. The presence of the molecular species 18:0/22:6ω3 was indicated in grey matter diacylglycerophosphorylethanolamine, 18:1/18:1 in white matter alk‐1‐enylacylglycerophosphorylethanolamine, and 16:0/18:1 in white matter diacylglycerophosphorylcholine.