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Regional Distribution of the Histamine Metabolite, tele ‐Methylimidazoleacetic Acid, in Rat Brain: Effects of Pargyline and Probenecid
Author(s) -
Khandelwal J. K.,
Hough Lindsay B.,
Green Jack Peter
Publication year - 1984
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1984.tb02708.x
Subject(s) - probenecid , pargyline , thalamus , medicine , metabolite , endocrinology , pons , hypothalamus , chemistry , cerebellum , histamine , monoamine oxidase , midbrain , caudate nucleus , medulla oblongata , biology , central nervous system , neuroscience , biochemistry , enzyme
Abstract:tele ‐Methylimidazoleacetic acid (t‐MIAA), a major brain histamine metabolite, was measured in nine rat brain regions by a gas chromatography‐mass spectrometric method that also measures the precursor amine, tele ‐methylhistamine (t‐MH). The t‐MIAA concentration of cerebellum, medulla‐pons, midbrain, caudate nucleus, hypothalamus, frontal cortex, hippocampus, and thalamus varied 15‐fold, hypothalamus showing the highest level (2.21 nmol/g) and cerebellum the lowest (0.15 nmol/ g). The concentrations of t‐MIAA and t‐MH were significantly correlated in all regions except midbrain, which had relatively more t‐MIAA. Probenecid did not alter whole‐brain t‐MIAA levels. Treatment with pargyline, an inhibitor of monoamine oxidase, lowered the t‐MIAA levels in all regions.