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Vanillic Acid, a Metabolite of 4‐Hydroxy‐3‐Methoxyphenylglycol and 4‐Hydroxy‐3‐Methoxymandelic Acid in Man
Author(s) -
Mådh Göran
Publication year - 1984
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1984.tb00930.x
Subject(s) - chemistry , metabolite , biochemistry
4‐Hydroxy‐3‐methoxyphenylglycol (HMPG) labelled with 14 C was used to study the metabolic fate of HMPG in six healthy volunteers. Besides conjugation and oxidation to 4‐hydroxy‐3‐methoxymandelic acid (HMMA, VMA) a minor portion, 8.4 ± 1.1% (mean ± SEM) was excreted as 14 C‐labelled vantllic acid (VA). To study if VA was formed from HMPG or HMMA (VMA), deuterium‐labelled HMPG ([ 2 H 3 ]HMPG) and HMMA ([ 2 H 6 ]HMMA) were simultaneously injected intravenously to seven healthy volunteers. The recovery of [ 2 H 3 ]VA from [ 2 H 3 ]HMPG was 8.3 ± 2.1% and the recovery of [ 2 H 6 ]VA from [ 2 H 6 ]HMMA was 9.0 ± 2.1%. The 2 H‐labelled VAs were probably formed by a decar boxylation reaction, in the case of HMPG after previous oxidation to HMMA.