Premium
Evidence for Multiple Muscarinic Receptor Subtypes in Human Brain
Author(s) -
Garvey Janice M.,
Rossor Martin,
Iversen Leslie L.
Publication year - 1984
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1984.tb00900.x
Subject(s) - pirenzepine , muscarinic acetylcholine receptor , muscarinic acetylcholine receptor m1 , quinuclidinyl benzilate , muscarinic acetylcholine receptor m4 , muscarinic acetylcholine receptor m2 , muscarinic acetylcholine receptor m5 , muscarinic acetylcholine receptor m3 , chemistry , endocrinology , receptor , medicine , biology , neuroscience , pharmacology , biochemistry
Pirenzepine, a compound with selective anti‐muscarinic activity, was used to distinguish muscarinic acetylcholine receptor subtypes in normal human brain. Hill coefficients and IC 50 values derived from the inhibition of specific [ 3 H] l ‐quinuclidinyl benzilate receptor binding suggest the presence of two muscarinic binding sites, differing both in affinity for pirenzepine and in tissue distribution.