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Hyperthermia Induces the Synthesis of a Heat Shock Protein by Polysomes Isolated from the Fetal and Neonatal Mammalian Brain
Author(s) -
Brown Ian R.
Publication year - 1983
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1983.tb13596.x
Subject(s) - polysome , hyperthermia , heat shock protein , protein biosynthesis , fetus , biology , translation (biology) , heat shock , shock (circulatory) , microbiology and biotechnology , chemistry , endocrinology , medicine , biochemistry , messenger rna , rna , ribosome , pregnancy , genetics , gene
Analysis of the cell‐free translation products of polysomes isolated from fetal brain and other organs indicates that elevation of maternal body temperature induces the synthesis of a heat shock protein of molecular weight 74,000 (74K). The newborn mammal is particularly sensitive to induction of the 74K protein. As early postnatal development proceeds, higher body temperatures are required to induce synthesis of the 74K heat shock protein.