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Effects of Acetylcholine on Sodium‐Dependent High‐Affinity Glutamate Transport in Rat Striatal Homogenates
Author(s) -
Kerkerian Lydia,
Nieoullon André
Publication year - 1983
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1983.tb13568.x
Subject(s) - oxotremorine , glutamatergic , cholinergic , glutamate receptor , carbachol , muscarinic acetylcholine receptor , acetylcholine , chemistry , striatum , endocrinology , medicine , muscarinic antagonist , nicotinic agonist , biology , receptor , biochemistry , dopamine
Incubation of rat striatal tissue in the presence of acetylcholine, carbachol, oxotremorine, or nicotine results in a significant decrease in the sodium‐dependent high‐affinity glutamate uptake (HAGU). The cholinergic inhibitory effect on glutamate transport is no more detectable in the presence of atropine, a cholinergic receptor antagonist. These data support the hypothesis that glutamatergic nerve ending activity in the striatum is modulated by cholinergic neurons. The effects would in volve both muscarinic and nicotinic presynaptic receptors located on the corticostriatal glutamatergic terminals.