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Acetylation of Synaptosomal Protein: Inhibition by Veratridine
Author(s) -
Berl Soil,
Nunez Ramiro,
Colon Arlene D.,
Clarke Donald D.
Publication year - 1983
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1983.tb12668.x
Subject(s) - veratridine , chemistry , tetrodotoxin , synaptosome , biochemistry , chromatography , acetylation , sodium , biophysics , biology , in vitro , organic chemistry , sodium channel , gene
Incubation of synaptosomes with [ 3 H]acetate results in rapid labeling of protein. Labeling is decreased in the presence of veratridine, and the effect of veratridine is blocked by tetrodotoxin. Most of the radioactivity can be removed by base or acid hydrolysis, and is probably incorporated as acetate; it is this fraction that is affected by the veratridine. The data suggest that veratridine stimulates deacetylation of synaptosomal protein. This raises the question whether acetylation‐deacetylation is involved in membrane function.