Premium
Vasoactive Intestinal Peptide Stimulation of Pineal Serotonin‐ N ‐Acetyltransferase Activity: General Characteristics
Author(s) -
Yuwiler Arthur
Publication year - 1983
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1983.tb11826.x
Subject(s) - vasoactive intestinal peptide , serotonin , organ culture , endocrinology , medicine , stimulation , receptor , biology , basal (medicine) , pineal gland , chemistry , neuropeptide , in vitro , biochemistry , circadian rhythm , insulin
Vasoactive intestinal polypeptide (VIP) stimulates basal serotonin‐ N ‐acetyltransferase (NAT) activity in pineals in organ culture and enhances the effects of catecholamines in inducing the enzyme. VIP appears to act postsynaptically; its action is independent of the beta receptor and is dependent upon protein synthesis. Its effects may be mediated by a receptor. The magnitude of the pineal response to VIP varies with age, is greater in pineals maintained in 48‐h organ culture than in those in acute culture, and can be detected in pineals from newborns after 48‐h organ culture. Intravenous administration of VIP can increase pineal NAT activity in vivo .