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Effect of α‐Fluoromethylhistidine on the Histamine Content of the Brain of W/W v Mice Devoid of Mast Cells: Turnover of Brain Histamine
Author(s) -
Maeyama Kazutaka,
Watanabe Takehiko,
Yamatodani Atsushi,
Taguchi Yoshitaka,
Kambe Hiroshi,
Wada Hiroshi
Publication year - 1983
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1983.tb11823.x
Subject(s) - histamine , endocrinology , medicine , histidine decarboxylase , forebrain , histamine n methyltransferase , histaminergic , diamine oxidase , reserpine , chemistry , biology , histidine , histamine h2 receptor , central nervous system , biochemistry , enzyme , receptor , antagonist
In the brains of W/W v mutant mice that have no mast cells, the histidine decarboxylase (HDC) level is as high as in the brain of congenic normal mice (+/+), but the histamine content is 53% of that of +/+ mice. The effects of a‐fluoromethylhistidine (α‐FMH) on the HDC activity and histamine content of the brain of W/W r and +/+ mice were examined. In both strains, 30 min after i.p. injection of α‐FMH the HDC activity of the brain had decreased to 10% of that in untreated mice. The histamine content decreased more gradually, and after 6 h about half of the control level remained in +/+ mice, whereas histamine had disappeared almost completely in W/W v mice. It is concluded that the portion of the histamine content that was depleted by HDC inhibitor in a short time is derived from non‐mast cells, probably neural cells. The half‐life of histamine in the brain of W/W v mice was estimated from the time‐dependent decrease in the histamine content of the brain after administration of a‐FMH: 48 min in the forebrain, 103 min in the midbrain, and 66 min in the hindbrain.