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Cyclic Nucleotide‐Dependent Protein Kinases and Some Major Substrates in the Rat Cerebellum After Neonatal X‐Irradiation
Author(s) -
Dolphin Annette C.,
Detre John A.,
Schlichter Doris J.,
Nairn Angus C.,
Yeh Hermes H.,
Woodward Donald J.,
Greengard Paul
Publication year - 1983
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1983.tb11321.x
Subject(s) - protein kinase a , cgmp dependent protein kinase , cerebellum , protein kinase r , mitogen activated protein kinase kinase , kinase , protein kinase c , biology , cyclic nucleotide , cyclin dependent kinase 2 , biochemistry , c raf , map2k7 , substrate (aquarium) , chemistry , microbiology and biotechnology , nucleotide , endocrinology , gene , ecology
The levels of cAMP‐dependent protein kinase (type I), of cGMP‐dependent protein kinase, of protein I and of a 23,000 MW substrate for the cGMP‐dependent protein kinase were measured in cerebella from normal rats and in the cerebella from rats in which a selective loss of interneurons in the cerebellar cortex had been produced by X‐irradiation. A decrease was observed in the concentrations of cAMP‐dependent protein kinase and of protein I, whereas an increase was observed in the concentrations of cGMP‐dependent protein kinase and of the 23,000 MW substrate. The data, taken together with the results of other studies, support the interpretation that cAMP‐dependent protein kinase and protein I are distributed throughout the cerebellum, but that cGMP‐dependent protein kinase and the 23,000 MW substrate are highly concentrated in Purkinje cells.