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Differential Effects of Fluoronorepinephrines on Phosphatidylinositol Turnover in Rat Pinealocytes
Author(s) -
Hauser George,
Kirk Kenneth L.,
Parks Joe M.
Publication year - 1983
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1983.tb09074.x
Subject(s) - pinealocyte , phosphatidylinositol , prazosin , endocrinology , chemistry , receptor , medicine , stimulation , adrenergic receptor , alpha (finance) , adrenergic , pineal gland , biology , biochemistry , signal transduction , circadian rhythm , antagonist , construct validity , nursing , patient satisfaction
(±)‐Norepinephrines (NAs), substituted with fluorine at positions 2, 5, and 6 of the ring, were compared with the unsubstituted compound with respect to their capacity for eliciting increased incorporation of [ 32 P]orthophosphate into phosphatidylinositol of pinealocytes. 5F‐NA and 6F‐NA were approximately equipotent with NA, whereas 2F‐NA required a higher concentration and gave lower maximum stimulation. Inhibition of these effects by prazosin confirmed the participation of α 1 ‐adrenergic receptors. The results are comparable with those reported for α 1 adrenergic receptor‐mediated events in other systems and different from the β‐adren‐ergic receptor‐mediated elevation of cyclic AMP in pinealocytes. These and earlier results emphasize the importance of the hydroxyl group at position 3 of the ring and at the β‐position of the side chain in catecholamine activation of the pineal α‐adrenergic receptors, which are involved in alterations of phospholipid metabolism.