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Loss of Ascorbic Acid from Injured Feline Spinal Cord
Author(s) -
Pietronigro Dennis D.,
Hovsepian Movses,
Demopoulos Harry B.,
Flamm Eugene S.
Publication year - 1983
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1983.tb09053.x
Subject(s) - ascorbic acid , spinal cord , paraplegia , spinal cord injury , cats , chemistry , medicine , endocrinology , anesthesia , biochemistry , food science , psychiatry
Feline spinal cord contains 0.97 m M ascorbic acid, as measured by the dinitrophenylhydrazine method. Greater than 90% is maintained in the reduced form. When functioning normally, the CNS conserves its ascorbic acid with a turnover rate of 2% per h. Following contusion injury severe enough to produce paraplegia, ascorbic acid is rapidly lost from injured spinal tissue. Thus, ascorbic acid is decreased 30% by 1 h and 50% by 3 h following injury. Oxidized ascorbic acid is increased at 1, but not 3, h following impact. As a consequence of its many functions in CNS, loss of ascorbic acid may contribute to derangements in spinal cord function following injury.