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Low Concentrations of Trifluoperazine Affect Striatal Cells in Culture
Author(s) -
Messer Anne,
Jennings Rosalie,
Maskin Paul
Publication year - 1983
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1983.tb09033.x
Subject(s) - trifluoperazine , striatum , calmodulin , acetylcholine , phenothiazine , apomorphine , pharmacology , drug , chemistry , affect (linguistics) , biology , endocrinology , biochemistry , dopamine , psychology , dopaminergic , communication , enzyme
Primary monolayer cultures of the newborn rat corpus striatum were treated with the phenothiazine trifluoperazine after various times in culture. When the drug is added to cells at least 3 weeks old, concentrations of 10 −7 and 10 −8 M appear morphologically identical to controls but show significant changes in synthesis of acetylcholine and γ‐aminobutyric acid, particularly the former. The results with these very low concentrations suggest that the drug has a highly specific effect directly on striatal cells, and that it is not acting via calmodulin.