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Changes in Muscarinic Binding in Distant Brain Regions Showing Neuronal Losses After Folic Acid Injections into the Substantia Innominata
Author(s) -
Wong P. T.H.,
McGeer E. G.,
Singh K.,
McGeer P. L.
Publication year - 1983
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1983.tb08151.x
Subject(s) - substantia innominata , substantia nigra , caudate nucleus , neuroscience , chemistry , thalamus , cortex (anatomy) , hippocampus , nucleus , nucleus basalis , gabaergic , cholinergic , dopamine , biology , cholinergic neuron , inhibitory postsynaptic potential , dopaminergic
Injection of folic acid (FA) into the nucleus substantia innominata (NSI) was found to decrease [ 3 H]quinuclidinyl benzilate ([ 3 H]QNB) binding in the frontal cortex, pyriform cortex, amygdala, and the NSI itself without changing the K d . Binding in the thalamus, caudate nucleus, hippocampus, and substantia nigra was not affected. [ 3 H]Flunitrazepam binding was unchanged in all eight regions studied. Previous work indicates FA injections into the NSI produce epileptiform activity and cause loss of GABAergic and possibly other neurons in the frontal and pyriform cortices, the amygdala, and thalamus. The reductions of [ 3 H]QNB binding in the first three of these regions are interpreted as indicating that many of the neurons lost are cholinoceptive, a finding that supports the previous hypothesis that activation of cholinergic projections from the NSI is an important part of the mechanism of cell loss in these regions.