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The Presence of Phospholipase D In Rat Central Nervous System Axolemma
Author(s) -
DeVries George H.,
Chalifour Robert J.,
Kanfer Julian N.
Publication year - 1983
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1983.tb08114.x
Subject(s) - axolemma , phospholipase c , phospholipase , phospholipid , phospholipase a2 , biology , central nervous system , biochemistry , white matter , enzyme , chemistry , endocrinology , myelin , medicine , membrane , radiology , magnetic resonance imaging
An axolemma‐enriched fraction prepared from a purified myelinated axon fraction isolated from rat CNS was found to contain phospholipase D at a specific activity similar to that of a microsomal fraction isolated from whole brain. There was a concomitant threefold enrichment in the specific activity of phospholipase D and acetylcholinesterase in the axolemma‐enriched fraction compared with the specific activities of these enzymes in the starting white matter whole homogenate. This axonal phospholipase D may be involved in remodeling of phospholipid, which in turn may affect axonal functions such as ion translocation.