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Neutral and Acid Sphingomyelinases of Rat Brain: Somatotopographical Distribution and Activity Following Experimental Manipulation of the Dopaminergic System In Vivo
Author(s) -
Sperker Erich R.,
Spence Matthew W.
Publication year - 1983
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1983.tb08112.x
Subject(s) - reserpine , striatum , acid sphingomyelinase , haloperidol , catecholaminergic , dopaminergic , in vivo , sphingomyelin , endocrinology , medicine , chemistry , biology , biochemistry , dopamine , cholesterol , microbiology and biotechnology
The activities of neutral, magnesium‐stimulated, and acid Sphingomyelinases were measured in five regions of rat brain. Neutral enzyme activity was 2‐3‐fold higher in striatum than in parietal cortex and 13‐fold higher than in cerebral white matter. Acid sphingomyelinase activity was more evenly distributed throughout these regions. Striatal neutral sphingomyelinase activity was not affected by treatment of rats with reserpine or haloperidol and was reduced (16%) by 6‐hydroxydopamine. Striatal acid sphingomyelinase was unaffected by reserpine and 6‐hydroxydopamine, and was increased (17%) by haloperidol. We conclude that neutral, magnesium‐stimulated sphingomyelinase activity differs in various regions of rat brain and is particularly enriched in the corpus striatum. However, it appears to be a constitutive component of tissue rather than a readily modulated regulatory element of the catecholaminergic system.