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In Vivo Elevation of Mouse Brain S‐Adenosyl‐L‐Homocysteine after Treatment with L‐Homocysteine
Author(s) -
Gharib A.,
Chabannes B.,
Sarda N.,
Pachéco H.
Publication year - 1983
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1983.tb08100.x
Subject(s) - homocysteine , adenosine , in vivo , pharmacology , intraperitoneal injection , medicine , endocrinology , plasma homocysteine , chemistry , biology , microbiology and biotechnology
Intraperitoneal coadministration of adenosine and L‐homocysteine markedly increased S ‐adenosyl‐ l ‐homocysteine in whole mouse brain, but further investigations showed that this elevation could also be produced following administration of l ‐homocysteine alone. The noted increase was maximal (+1325%) 10 min after treatment, remaining at about this level for 30‐40 min before returning to control values after 180 min. Cerebral adenosine levels were decreased after treatment with l ‐homocysteine, adenosine, or these two substances in combination.