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Differences Between d ‐Fenfluramine and d ‐Norfenfluramine in Serotonin Presynaptic Mechanisms
Author(s) -
Borroni E.,
Ceci A.,
Garattini S.,
Mennini T.
Publication year - 1983
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1983.tb08065.x
Subject(s) - fenfluramine , serotonin , chemistry , pharmacology , endocrinology , medicine , biology , biochemistry , receptor
The abilities of d ‐fenfluramine ( d ‐F) and that of d ‐norfenfluramine ( d ‐NF) to inhibit [ 3 H]serotonin ([ 3 H]5‐HT) accumulation in normal and reserpinized synaptosomes were compared to establish to what extent the serotonin‐releasing activity of the two drugs might contribute to reduced accumulation of [ 3 H]5‐HT. The results indicate that the inhibitory action of ( d ‐NF) on [ 3 H]5‐HT accumulation is due principally to its ability to release [ 3 H]5‐HT. In contrast, the interference of release in accumulation studies does not seem to play an important role for d ‐F, suggesting that release from the granular pool and true uptake inhibition are two different mechanisms by which d ‐F affects serotonin neurons in vitro .