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Hypoprolactinemic Action of Calcitonin and the Tuberoinfundibular Dopaminergic System
Author(s) -
Clementi G.,
Nicoletti F.,
Patacchioli F.,
Prato A.,
Patti F.,
Fiore C.E.,
Matera M.,
Scapagnini U.
Publication year - 1983
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1983.tb08063.x
Subject(s) - dopaminergic , endocrinology , medicine , calcitonin , neurochemical , prolactin , dopamine , 3,4 dihydroxyphenylacetic acid , chemistry , hormone , biology , serotonin , homovanillic acid , receptor
The effects of calcitonin on neurochemical parameters related to the tuberoinfundibular dopaminergic system have been investigated in an attempt to elucidate how calcitonin decreases serum prolactin levels. Intracerebroventricular human or salmon calcitonin injection decreases serum prolactin, medial basal hypothalamic dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) and hypophysial DA and increases hypophysial DOPAC. Results suggest that calcitonin may decrease prolactin secretion via the tuberoinfundibular dopaminergic system.