Premium
Effect of Electroconvulsive Shock on the Uptake and Release of Noradrenaline and 5‐Hydroxytryptamine in Rat Brain Slices
Author(s) -
Minchin M. C. W.,
Williams J.,
Bowdler J. M.,
Green A. R.
Publication year - 1983
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1983.tb08044.x
Subject(s) - electroconvulsive shock , electroconvulsive therapy , pharmacology , neuroscience , shock (circulatory) , norepinephrine , chemistry , medicine , psychology , dopamine
The uptake and release of [ 3 H]noradrenaline and [ 3 H]‐5‐hydroxytryptamine (5‐HT) were studied in cerebral cortex slices from rats 30 min and 24 h after a single electroconvulsive shock (ECS) and 24 h after a series of five shocks given over 10 days. Both the K m and V max for 5‐HT uptake were lower than controls 24 h after a single ECS, whereas after 5 ECS spread over 10 days both parameters remained depressed, though only the fall in V max was significant. Noradrenaline uptake was not altered after a single ECS, but the V max and K m were elevated following chronic ECS treatment. Neither ECS treatment schedule had any effect on the potassium‐stimulated release of either transmitter. It is possible that the changes in monoamine uptake seen following ECS are an adaptive response to alterations in the synaptic cleft concentration of these transmitters.