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Cortical GABA Turnover During Bicuculline Seizures in Rats
Author(s) -
Chapman Astrid G.,
Evans Mary C.
Publication year - 1983
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1983.tb04823.x
Subject(s) - bicuculline , gaba transaminase , chemistry , medicine , endocrinology , gaba receptor antagonist , turnover , gamma aminobutyric acid , biochemistry , biology , gabaa receptor , enzyme , glutamate decarboxylase , receptor , management , economics
The rate of cortical γ‐aminobutyric acid (GABA) turnover was estimated by determining the rate of GABA accumulation following inhibition of GABA transaminase by γ‐vinyl‐GABA (1.5 g/kg, i.v.) in paralysed, ventilated rats. During 1 h of bucuculline‐induced seizures (1.2 mg/kg, i.v.) the rate of accumulation of cortical GABA level is approximately threefold greater than in the control group receiving γ‐vinyl‐GABA alone, suggesting that the GABA shunt activity increases in parallel with the increase in overall cortical metabolic rate observed during bicuculline seizures. Pretreatment with γ‐vinyl‐GABA did not affect the bicuculline‐induced changes in other major cortical amino acids.