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Changes in Hexokinase Isoenzymes in Regions of Rat Brain During Insulin‐Induced Hypoglycemia
Author(s) -
Kaur Gurcharan,
Singh Rameshwar,
Baquer Najma Zaheer
Publication year - 1983
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1983.tb04780.x
Subject(s) - hexokinase , isozyme , hypoglycemia , cerebellum , insulin , endocrinology , medicine , biochemistry , chemistry , biology , enzyme , glycolysis , metabolism
Activities of hexokinase isoenzymes were determined during insulin‐induced hypoglycemia in soluble and total particulate fractions from three regions of rat brain. Type I hexokinase isoenzyme activity showed a small decrease in both soluble and particulate fractions from the cerebral hemispheres. In cerebellum and brain stem, however, Type I isoenzyme showed a decrease only in the soluble fraction. A significant increase was observed in hexokinase Type II isoenzyme from both the fractions, in all the three brain regions 1 h after insulin administration.