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Further Studies on 4‐Hydroxy‐3‐Methoxyphenylglycol Oxidation in Humans: Effect of Pool Expansion and Stereochemistry
Author(s) -
Mådh Göran
Publication year - 1983
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1983.tb04743.x
Subject(s) - chemistry , stereochemistry
The in vivo oxidation of the norepinephrine metabolite 4‐hydroxy‐3‐methoxyphenylglycol (HMPG) to 4‐hydroxy‐3‐methoxymandelic acid was studied in man with two different doses of deuterium‐labeled HMPG and a tracer dose of [ 14 C]HMPG. HMPG oxidation appeared to be dose‐dependent with an oxidation of 62–70% for doses below or equal to 2.2 μmol. With the use of a capillary column coated with an optically active phase (Chirasil‐Val) and gas chromatography mass‐spectrometry the human urinary excretions of the two stereoisomers of deuterium‐labelled HMPG (free + conjugates) were found to be equal.