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Effect of Electroconvulsive Shock on Muscarinic Cholinergic Receptors in Rat Cerebral Cortex and Hippocampus
Author(s) -
Lerer Bernard,
Stanley Michael,
Demetriou Sàndra,
Gershon Samuel
Publication year - 1983
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1983.tb00880.x
Subject(s) - electroconvulsive shock , muscarinic acetylcholine receptor , quinuclidinyl benzilate , hippocampus , atropine , cholinergic , electroconvulsive therapy , medicine , endocrinology , cerebral cortex , neuroscience , acetylcholine , muscarinic acetylcholine receptor m4 , receptor , chemistry , psychology
Single electroconvulsive shock (ECS) induced no change in [ 3 H]quinuclidinyl benzilate ([ 3 H]QNB) binding to muscarinic cholinergic receptors in rat cortex and hippocampus. ECS administered once daily for 7 days induced a significant reduction in [ 3 H]QNB binding in both brain areas. Concurrent ECS reversed the significant increase in cortical [ 3 H]QNB binding induced by chronic atropine administration. These findings may have relevance to the antidepressant or amnestic effects of electroconvulsive therapy.