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Studies on [ 3 H]Diazepam and [ 3 H]Ethyl‐β‐Carboline Carboxylate Binding to Rat Brain In Vivo . II. Effects of Electroconvulsive Shock
Author(s) -
Nutt D. J.,
Minchin M. C. W.
Publication year - 1983
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1983.tb00857.x
Subject(s) - diazepam , in vivo , hippocampus , striatum , cerebral cortex , electroconvulsive shock , cerebellum , chemistry , endocrinology , medicine , pharmacology , neuroscience , anesthesia , biology , microbiology and biotechnology , dopamine
In vivo specific binding of [ 3 H]diazepam was not altered by a single electroconvulsive shock given 5, 30, or 60 min, or 24 h previously, nor 24 h after the last of 10 daily shocks. Similarly, in vivo [ 3 H]ethyl‐β‐carboline carboxylate binding was not changed in the brains of animals that had been given a single electroconvulsive shock 30 min previously or a series of 10 daily shocks. Brain areas examined included cerebral cortex, hippocampus, cerebellum, and striatum. However, cortical binding of [ 3 H]diazepam was increased by 32% in animals which were present in the same room while another was being injected and killed. This may represent a response to stress and/or anxiety.