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Neuronal [ 3 H]Benzodiazepine Binding and Levels of GABA, Glutamate, and Taurine Are Normal in Huntington's Disease Cerebellum
Author(s) -
Kish Stephen J.,
Shannak Kathleen S.,
Perry Thomas L.,
Hornykiewicz Oleh
Publication year - 1983
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1983.tb00852.x
Subject(s) - cerebellum , glutamate receptor , gabaa receptor , taurine , huntington's disease , endocrinology , medicine , neuroscience , benzodiazepine , chemistry , receptor , biology , biochemistry , disease , amino acid
Alterations in one subunit of the proposed GABA receptor complex, namely, the GABA receptor, have been observed in Huntington's disease cerebellum. We measured binding to a second subunit, the benzodiazepine binding site, in the autopsied cerebellum of 12 patients dying with adult‐onset Huntington's disease. Neuronal benzodiazepine ([ 3 H]flunitrazepam) binding density (B max ) and affinity in cerebellar cortex of the Huntington's disease patients were not significantly different from control values. Similarly, maximal GABA stimulation of benzodiazepine binding was normal in the Huntington's disease cerebellum. In addition, no significant changes were observed in the concentrations of GABA, glutamate, and taurine in cerebellar cortex, nor of GABA in the dentate nucleus.