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Cerebral Glutamic Acid Decarboxylase Activity and γ‐Aminobutyric Acid Concentrations in Mice Susceptible or Resistant to Audiogenic Seizures
Author(s) -
Sykes C. C.,
Horton R. W.
Publication year - 1982
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1982.tb12597.x
Subject(s) - glutamate decarboxylase , aminobutyric acid , glutamic acid , medicine , endocrinology , chemistry , gamma aminobutyric acid , biology , biochemistry , enzyme , amino acid , receptor
DBA/2 mice between 21 and 28 days of age are highly susceptible to sound‐induced seizures. Drug studies suggest a possible deficit of γ‐Aminobutyric acid (GABA)‐mediated neurotransmission may be involved. We have measured the whole brain GABA concentration and glutamic acid decar‐boxylase activity in DBA/2 mice at various ages before, during, and after the period of maximal susceptibility to audiogenic seizures. Corresponding determinations were carried out on age‐matched TO mice, a strain much less susceptible to audiogenic seizures than DBA/2 mice at all ages. No significant differences in GABA concentration or glutamic acid decarboxylase activity were found between strains at any age. The susceptibility of DBA/2 mice to audiogenic seizures does not result from a gross inability to synthesise or store GABA.