Premium
Noncorrelation of Choline Kinase or ATP Citrate Lyase with Cholinergic Activity in Rat Brain
Author(s) -
Harvey S. A. K.,
Leong S. F.,
Clark J. B.
Publication year - 1982
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1982.tb12595.x
Subject(s) - choline acetyltransferase , choline kinase , atp citrate lyase , cholinergic , acetylcholinesterase , choline , biochemistry , chemistry , acetylcholine , cholinergic neuron , biology , enzyme , endocrinology , citrate synthase , phospholipid , membrane , phosphatidylcholine
The activity of choline acetyltransferase was used as an index of cholinergic structures in regions of rat brain. The activities of ATP citrate lyase and choline kinase correlated poorly with cholinergic activity in whole tissue fractions, contrasting with the good correlation between acetylcholinesterase and choline acetyltransferase. Choline acetyltransferase was preferentially localised in synaptosomes prepared from regions of high (striatum) or intermediate (cortex, medulla oblongata/pons) cholinergic activity. In general, this was not true for either choline kinase or ATP citrate lyase.