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Differential Effects of Long‐Term Electroconvulsive Shock on Brain Levels of Enkephalin and Humoral‐Endorphin
Author(s) -
Same Y.,
Weissman B. A.,
Urca G.
Publication year - 1982
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1982.tb12594.x
Subject(s) - electroconvulsive shock , enkephalin , endogenous opioid , endogeny , opioid peptide , opioid , shock (circulatory) , neuroscience , neuropeptide , beta endorphin , morphine , anesthesia , medicine , endocrinology , psychology , receptor
Electroconvulsive shock (ECS) administrations repeated for 10 consecutive days cause an elevation in the opioid content of the rat brain. Two different endogenous opioids, enkephalin and humoral‐endorphin, undergo independent changes that differ in both their time course and intracerebral localization. These metabolic changes parallel long‐term behavioral modifications such as the development and dissipation of tolerance to the analgesic effect of ECS. The activation of two different, independent, endogenous opioid systems by ECS is in agreement with previous behavioral and pharmacological studies.