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Immunological Studies of Human Monoamine Oxidases
Author(s) -
Brown G. K.,
Powell J. F.,
Craig I. W.
Publication year - 1982
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1982.tb12564.x
Subject(s) - monoamine oxidase , pargyline , enzyme , antiserum , radioimmunoassay , platelet , biochemistry , monoamine neurotransmitter , chemistry , human placenta , placenta , biology , antigen , fetus , immunology , serotonin , pregnancy , receptor , genetics
Antisera have been raised against monoamine oxidase preparations from human placenta and platelets. These antisera have been employed to characterize membrane‐bound enzyme from a variety of human sources including liver, heart, and brain. The comparisons were based on a displacement radioimmunoassay system with soluble placenta! monoamine oxidase, previously labelled specifically with [ 3 H]pargyline, as antigen. All forms of enzyme investigated demonstrated immunological cross reaction; however, the placental enzyme appeared to possess determinants not exhibited by the enzyme from the platelets or other tissues examined.