Premium
Role of Elongation Factor 1 in the Translational Control of Rodent Brain Protein Synthesis
Author(s) -
Vargas Rocío,
Castañeda Mario
Publication year - 1982
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1982.tb12542.x
Subject(s) - rodent , elongation factor , eukaryotic translation elongation factor 1 alpha 1 , neuroscience , protein biosynthesis , biology , microbiology and biotechnology , chemistry , biochemistry , ecology , gene , ribosome , rna
The translational control of protein synthesis during early postnatal neural development and aging was examined in the mouse and the rat. The activity of brain elongation factor 1 (bEF‐1) was found to decrease exponentially with age and to decline parallel to the age‐dependent decrease in total protein synthesis in both rodents. This decrement in bEF‐1 activity fell within the range of reported age‐related decreases in protein synthesis in in vitro systems. The factor was present in multiple forms; the lighter species predominated in older animals, whereas the young light form apparently disappeared with increasing age, and was replaced by others arising from the heavy form. Elongation factor 1 derived from young brains functioned as a rate‐limiting component in polypeptide synthesis in previously saturated adult systems. The data suggest that bEF‐1 has an important modulatory effect on total brain protein synthesis.