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Enhancement of Depolarization‐Induced Release of γ‐Aminobutyric Acid from Brain Slices by Antibodies to Ganglioside
Author(s) -
Frieder Brina,
Rapport Maurice M.
Publication year - 1982
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1982.tb12534.x
Subject(s) - depolarization , ganglioside , aminobutyric acid , chemistry , antibody , biophysics , neuroscience , biochemistry , biology , immunology , receptor
The effect of antibodies to G M1 ganglioside on release of neurotransmitters from rat brain slices was studied. Depolarization‐induced (40 mM‐KCl or veratrine) release of γ‐aminobutyric acid was markedly enhanced. Depolarization‐induced release of norepinephrine was only slightly enhanced, whereas that of serotonin was unaffected. No effect on spontaneous release was observed for any of these three neurotransmitters. These results show that antibodies that can bind to synaptic membrane antigens may alter neurotransmitter release and that antibodies directed against G M1 ganglioside exhibit a measure of specificity in producing such an effect.