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Cyclocreatine Phosphate, an Analogue of Creatine Phosphate, Does not Improve Hypoxic Tolerance in Mice
Author(s) -
Artru Alan A.,
Michenfelder John D.
Publication year - 1982
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1982.tb11517.x
Subject(s) - creatine , hypoxia (environmental) , phosphate , medicine , endocrinology , biology , biochemistry , chemistry , oxygen , organic chemistry
Dietary cyclocreatine has been reported to increase brain highenergy stores in mice and to prolong the generation and utilization of these stores following decapitation. A possible cerebral protective action after 50 days of dietary cyclocreatine 0.5% and 1.0% was therefore examined in mice. Cyclocreatine 0.5% did not increase survival time during hypoxia (5% 0 2 ). Cyclocreatine 1.O% in the absence of hypoxia caused significant mortality and decreased weight in survivors despite prophylactic antibiotic treatment. Dietary cyclocreatine offers no cerebral protection against hypoxia in mice.