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Regulation of Cyclic AMP Accumulation in a Rat Sympathetic Ganglion: Effects of Vasoactive Intestinal Polypeptide
Author(s) -
Volle Robert L.,
Patterson Brian A.
Publication year - 1982
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1982.tb11516.x
Subject(s) - vasoactive intestinal peptide , vasoactive , endocrinology , medicine , ganglion , sympathetic ganglion , chemistry , sympathetic nervous system , biology , microbiology and biotechnology , neuropeptide , neuroscience , receptor , blood pressure
Cyclic AMP accumulation in rat superior cervical ganglia during synaptic activity occurs by a noncholinergic, nonadrenergic process. Both preganglionic nerve stimulation and 4‐aminopyridine increase ganglion cyclic AMP levels in the presence of atropine or phentolamine. Of the polypeptides tested as putative transmitters, vasoactive intestinal polypeptide (10 −6 M) causes ganglion cyclic AMP accumulation comparable to that produced by preganglionic nerve stimulation.