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Analysis by Transfer Electrophoresis of Reactivity of IgG with Brain Proteins in Multiple Sclerosis
Author(s) -
Newcombe J.,
Glynn P.,
Cuzner M. L.
Publication year - 1982
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1982.tb11515.x
Subject(s) - multiple sclerosis , cerebrospinal fluid , antiserum , central nervous system , antibody , experimental autoimmune encephalomyelitis , encephalomyelitis , immunology , chemistry , incubation , pathology , medicine , biochemistry , endocrinology
Central nervous system proteins, immobilized on cellulose nitrate sheets, can be identified by incubation with specific antisera. Using this technique, no disease‐related antibodies against CNS proteins were detected in the cerebrospinal fluid, brain extracts, or sera from cases of multiple sclerosis, although a positive response was seen in sera from animals with experimental autoimmune encephalomyelitis.