Premium
Inhibition by l ‐Phenylalanine of Tyrosine Transport by Synaptosomal Plasma Membrane Vesicles: Implications in the Pathogenesis of Phenylketonuria
Author(s) -
Aragón M. C.,
Giménez C.,
Valdivieso F.
Publication year - 1982
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1982.tb11513.x
Subject(s) - phenylalanine , tyrosine , vesicle , pathogenesis , chemistry , biochemistry , phenylketonurias , endocrinology , membrane , medicine , biology , amino acid
The effect of l ‐phenylalanine on the transport of tyrosine was studied using membrane vesicles from rat brain synaptosomes. Phenylalanine, which is accumulated in phenylketonuria, competitively inhibits tyrosine uptake at concentrations similar to those found in phenylketonuric patients, with a K 1 of the same order of the K m for tyrosine. This inhibition could be responsible for the depletion of catecholamines observed in phenylketonuria.