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Cytochrome Reductase Activities in Rat Brain Microsomes During Development
Author(s) -
Takeshita Masazumi,
Miki Mayumi,
Yubisui Toshitsugu
Publication year - 1982
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1982.tb11495.x
Subject(s) - medulla oblongata , microsome , reductase , cerebellum , endocrinology , medicine , biology , medulla , midbrain , biochemistry , chemistry , enzyme , central nervous system
Postnatal developmental alterations of microsomal NADH‐cyto‐chrome b 5 reductase and NADPH‐cytochrome c reductase activities were determined in the brain of rats. The reductase activities increased from a low level in the immature brain to a maximum level at 23 to 30 days of age, and then decreased slightly to a plateau. The periods of the activity increments were in accord with those of the enhancement of microsomal fatty acid elongation. The specific activities of these reductases were high in cerebral hemispheres and medulla oblongata, intermediate in midbrain, and lowest in cerebellum of the four regions of 20‐day‐old rat brain.