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Distribution of Angiotensin‐Converting Enzyme Activity in Specific Areas of the Rat Brain Stem
Author(s) -
Chevillard Claude,
Saavedra Juan M.
Publication year - 1982
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1982.tb10883.x
Subject(s) - locus coeruleus , area postrema , raphe nuclei , reticular formation , angiotensin converting enzyme , medicine , endocrinology , enzyme assay , dorsal raphe nucleus , chemistry , raphe , enzyme , biology , central nervous system , serotonin , biochemistry , serotonergic , receptor , blood pressure
Angiotensin‐converting enzyme (ACE) activity was measured by a radiochemical assay in 30 specific areas of the rat brain stem. ACE activity is unevenly distributed, with a 60‐fold difference between the lowest and the highest activity. The area postrema exhibits the highest activity. The substantia nigra (pars reticulata), the locus coeruleus, the areas A 1 and A 2 , the nuclei commissuralis, and tractus solitarii have a substantial ACE activity, whereas the lowest activity is found in the raphe nuclei and the nuclei of the reticular formation.