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Effects of Kainic Acid on High‐Energy Metabolites in the Mouse Striatum
Author(s) -
Retz Konrad C.,
Coyle Joseph T.
Publication year - 1982
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1982.tb10872.x
Subject(s) - kainic acid , striatum , chemistry , neuroscience , biochemistry , biology , dopamine , glutamate receptor , receptor
Intrastriatal injection of either kainic acid (0.35 μg) or ibotenic acid (7.0 μg) in the mouse causes a profound and selective degeneration of striatal neurons accompanied by a secondary astrocytic response. The kainate injection (0.35 μg) resulted in significant decrements in the striatal levels of phosphocreatine and ATP by 30 min, a progressive reduction in adenosine phosphates between 30 min and 48 h, and a decrease in energy charge; whereas lactate levels increased by 44% at 2 h, glucose levels fell by 56%. Two hours after intrastriatal injection of ibotenic acid (7.0 μg) similar alternations in striatal high‐energy phosphates and glucose disposition were found. Prior decortication protected against the neurotoxic effects of kainate in the mouse striatum and prevented the alterations in high‐energy phosphates at 2 h although lactate levels increased by 212%. These findings in vivo are consistent with the hypothesis that the neurotoxic effects of acidic excitatory amino acids involve a profound activation of energy consumption by affected neurons.