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DNA Turnover in Rat Cerebral Cortex
Author(s) -
PerroneCapano C.,
D'Onofrio G.,
Giuditta A.
Publication year - 1982
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1982.tb10852.x
Subject(s) - cerebral cortex , dna , cortex (anatomy) , thymidine , biology , specific activity , nuclear dna , period (music) , dna synthesis , metabolism , fraction (chemistry) , chemistry , biochemistry , microbiology and biotechnology , endocrinology , neuroscience , chromatography , gene , enzyme , mitochondrial dna , physics , acoustics
After the intracranial injection of [methyl‐ 3 H]thymidine the specific activity of rat cortical DNA increases rapidly, reaching a maximum at about 5 h. More than half of the radioactive DNA disappears from the tissue in the following few hours. During the same period of time the concentration of radioactive DNA in liver remains essentially constant. Minor variations occur in both organs after 41 h. An apparent rapid turnover of DNA is also present in a fraction of purified neuronal perikarya prepared from the cerebral cortex.