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Effects of Anticonvulsants on the Formation of γ ‐Hydroxybutyrate from γ ‐Aminobutyrate in Rat Brain
Author(s) -
Whittle Susan R.,
Turner Anthony J.
Publication year - 1982
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1982.tb08710.x
Subject(s) - gamma hydroxybutyrate , aldehyde , succinic acid , chemistry , pharmacology , biochemistry , biology , catalysis
The conversion of γ‐aminobutyrate (GABA) via succinic semialdehyde to γ‐hydroxybutyrate has been examined in rat brain homogenates. A number of anticonvulsants, including sodium valproate and phenobarbitone, inhibited this metabolic pathway. These results are interpreted in the light of the characteristics of aldehyde reductases known to reduce succinic semialdehyde.