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Postnatal Developmental Changes in Fucosyltransferase Activity in Rat Brain
Author(s) -
Léon Monique,
Broquet Pierre,
Morélis Renée,
Louisot Pierre
Publication year - 1982
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1982.tb08020.x
Subject(s) - fucosyltransferase , fucose , fucosidase , enzyme , stimulation , period (music) , enzyme assay , biology , medicine , endocrinology , chemistry , biochemistry , glycoprotein , physics , acoustics
GDP‐fucose:asialofetuin fucosyltransferase activity was studied during the postnatal development of rat brain. The enzymatic activity was very low during the first days of life and reached a maximum level around 21 days. This increase in enzymatic activity was characterized by two periods of rapid change. A rapid increase occurred between 3 and 7 days after birth, followed by a slow increase from 7 to 17 days, then a new rapid change from 17 to 21 days. Stimulation of the enzymatic activity by Triton X‐100 increased with age. The developmental profiles of GDP‐fucose pyrophosphatase and fucosidase did not change during this period.