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The Complete Amino Acid Sequence of Human P2 Protein
Author(s) -
Suzuki Masaru,
Kitamura Kunio,
Sakamoto Yasushi,
Uyemura Keiichi
Publication year - 1982
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1982.tb08017.x
Subject(s) - cyanogen bromide , amino acid , sedimentation equilibrium , chemistry , dynamic equilibrium , peptide sequence , equilibrium constant , biochemistry , equilibrium thermodynamics , sequence (biology) , protein primary structure , stereochemistry , thermodynamic equilibrium , enzyme , thermodynamics , gene , physics
The complete amino acid sequence of P2 protein from human peripheral nerve myelin was determined from nine staphylococcal protease peptides and four cyanogen bromide peptides. Human P2 protein is composed of 131 amino acids and has a molecular weight of 14,818. Compared to bovine P2 protein, there are replacements at nine positions (human↔bovine): 18(Asp↔Glu), 39(Thr↔Arg), 56(Thr↔Pro), 83(Ile↔Thr), 87(Gln↔Ala), 96(Arg↔Lys), 100(Lys↔Asn), 115 (Ala↔Val), and 121(Gly↔Asp).